The Second Murray Group was the 1910 iteration of the League of Extraordinary Gentlemen. It consisted of Mina Murray, Allan Quatermain, Orlando, Thomas Carnacki, and A.J. Raffles. They were recruited by Mycroft Holmes. This League was the first to encounter Oliver Haddo, and put into action the events that would begin Haddo's mission to create the Antichrist.
The League also encountered Janni Nemo during her rampage in London's East-End. During this period, Orlando was in his male form and Allan Quatermain went under the identity of Allan Quatermain, Jr..